2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Serine Racemase (SR)

Serine Racemase (SR)

Serine Racemase; SR

Serine Racemase converts L-serine into D-serine, which acts as an agonist of the NMDA receptor, regulates the neuronal excitability, synaptic transmission, and is involved in neuroprotective mechanisms. Serine Racemase is mainly located in the cytoplasm of neurons, especially in the synaptic region. Serine Racemase dysfunction could lead to neurological diseases, such as ischemic stroke and schizophrenia[1].

Serine Racemase (SR) Related Products (2):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W115558
    L-Serine-O-sulfate potassium
    		Inhibitor
    L-Serine-O-sulfate potassium is a serine racemase (Srr) inhibitor. L-Serine-O-sulfate potassium attenuates the chronic constriction injury (CCI)-induced increases in NO levels, nNOS phosphorylation at Ser847, PKC-dependent GluN1 phosphorylation at Ser896, and the development of mechanical allodynia in mice. L-Serine-O-sulfate potassium can be used for the research of peripheral neuropathy.
    L-Serine-O-sulfate potassium
  • HY-162652
    HSR-IN-1
    		Inhibitor
    HSR-IN-1 (Compound 28) is an effective hSR (human serine racemase) inhibitor. In the presence of the cofactor Pyridoxal 5'-phosphate monohydrate (HY-W011727A), HSR-IN-1 has a Kd value of 5.4 μM and an IC50 of 18.3 μM for hSR, while the IC50 of HSR-IN-1 alone is 4.7 μM. HSR-IN-1 can be used for research on central nervous system diseases.
    HSR-IN-1